Nov 8, 2025; Madison, Wisconsin, USA; Washington Huskies wide receiver Denzel Boston (12) catches a pass to score a touchdown during the second quarter against the Wisconsin Badgers at Camp Randall Stadium. Mandatory Credit: Jeff Hanisch-Imagn Images | Jeff Hanisch-Imagn Images The San Francisco 49ers hold all the cards to open the second round of the 2026 NFL Draft after trading back to No. 33 last night.With the first pick of the second round, teams are surely checking in to see if the 49ers would be willing to trade down, and that seems like a real possibility with the chance to pick up additional draft capital.But there are also several players available at No. 33 that San Francisco would’ve likely considered at No. 27, so they very well could just sit pat and pick.With Day 2 of the draft starting soon, let’s look at the available players on the board and see the five best fits for the 49ers at No. 33.WR Denzel BostonIf you’ve been tracking the 49ers’ pre-draft interests, you’ve likely heard of Boston.The 49ers did a ton of due diligence on wide receivers in this class, and Boston was a name who was expected to go in Round 1 that slid back to the top of the second round.
And he’ll probably go quite early, if not at No. 33.At 6’4, 210 pounds, Boston is a bigger receiver, with our Kyle Posey giving him the comp of Mike Evans, who coincidentally is also a Niner. What better way to learn and develop than being around Evans every single day?Boston tested very well, with his three-cone time standing out, and his ball skills stand out. He’s a very viable target at No. 33.S Emmanuel McNeil-WarrenAnother player widely mocked to go in the first round, McNeil-Warren sits near the top of most big boards heading into Day 2.Heading into the draft, I’ve mentioned how safety could be an under-the-radar pick for San Francisco’s first selection.
Their position group underwhelmed in 2025, and could use an upgrade. If there’s a group where a rookie can come in and make the most impact in 2026, it might be safety.That’s where McNeil-Warren fits in. He’s got good arm length and can play the enforcer role that Talanoa Hufanga played in San Francisco as a robber.
He’s one of the better values at the top of Round 2.CB Jermod McCoyThis one is purely up to the medicals and might be why San Francisco could have him completely off their board.But McCoy has the talent of a first-round cornerback, and he’s athletic and physical enough as a man corner. Having good man-coverage corners is always a need, and the 49ers could use an upgrade at the position after inconsistent play from Renardo Green last year.This is also a spot where a highly-drafted rookie could come in and instantly be a contributor.OG Chase BisontisIt might be unexpected to take a guard this early, but San Francisco’s biggest need is their left guard spot, and Chase Bisontis could fill that hole.He might be more suitable with a trade back, but he also had some first-round buzz and should go early on Day 2.
So, why not at No. 33?Bisontis seems like a solid fit as a zone blocker that can be tough and nasty, and could be a starter at guard for the foreseeable future as he develops.EDGE Cashius HowellThe 49ers could use some extra pass rush after ranking No. 32 in sacks last year. Nick Bosa and Mykel Williams are returning from torn ACLs, but the team lost Bryce Huff and could use some more depth there.That’s where Cashius Howell and his 11.5 sacks in 2025 fit in. Howell has solid bend and athleticism, and might be more of a situational pass-rusher at first, but that’s exactly what San Francisco needs.