"Well, here we are! I've been proud to lead this campaign."(Cuban later apologized for his wording, but added that "I stand by my opinion that he does not like being challenged publicly.")Trump's history with women is complex, with a record of inflammatory comments, lawsuits, and contentious political actions such as laying the groundwork to overturn Roe v. Wade.

However, Trump has also made notable gains with women voters. In 2024, 45% of women voted for Trump compared to 55% of men — a narrower gender gap than in 2016 and 2020, according to the Center for American Women and Politics.During his second non-consecutive term, Trump has named women to several historic appointments in his administration, including the first female White House chief of staff and the youngest-ever press secretary.According to the Center for American Women and Politics, one-third of Trump's original Cabinet and Cabinet-level appointments — eight out of 24 — were women.However, three of the most powerful women in Trump's administration have recently lost their roles.

In April, the president fired Attorney General Pam Bondi, weeks after firing another, Homeland Security Secretary Kristi Noem. Labor Secretary Lori Chavez-DeRemer also resigned on Monday following investigations into alleged misconduct.When reached for comment in March 2025, the White House referred Business Insider to the president's comments from a 2025 White House event for Women's History Month in which he praised the women in his Cabinet and said he was "thrilled to say that we have more women in our Cabinet than any Republican president in the history of our country."Meet the most powerful women in the Trump administration.Susie Wiles, White House chief of staffWhite House chief of staff Susie Wiles looks on as US President Donald Trump speaks in the Oval Office of the White House after announcing reciprocal tariffs, in Washington, DC, on February 13, 2025.

Trump announced that he would impose "reciprocal tariffs" on trading partners, opening new fronts in his trade war. The move would match US tariff rates on imports to the levels that other countries impose on US goods.ANDREW CABALLERO-REYNOLDS/AFP via Getty ImagesAt his 2024 election victory party, Trump said that Susie Wiles "likes to stay in the background," but she has emerged as a key figure in Trump's political operation.Wiles is the first woman in US history to serve as a president's chief of staff. A longtime member of Trump's inner circle, she ran his Florida campaigns in 2016 and 2020 and acted as his campaign manager in 2024."Susie is tough, smart, innovative, and is universally admired and respected," Trump wrote on Truth Social when announcing Wiles as his White House chief of staff.

"Susie will continue to work tirelessly to Make America Great Again."In a March 2025 interview on Lara Trump's "My View" show on Fox News, Wiles described herself as "quietly competitive.""I see my job as just sort of keeping the trains on the tracks and running on time here, so that the subject matter experts, and particularly the president and the vice president, can do what they need to do to fix the country," she said.In a series of interviews with Vanity Fair published in December, Wiles described Trump as having an "alcoholic's personality," Vice President JD Vance as a "conspiracy theorist," and said she was "aghast" at Elon Musk's dismantling of the United States Agency for International Development.Wiles called the Vanity Fair article a "disingenuously framed hit piece" in a post on X, but did not dispute any of the magazine's reporting. The Trump administration stood behind her, with Karoline Leavitt telling Business Insider that "President Trump has no greater or more loyal advisor than Susie," adding, "The entire Administration is grateful for her steady leadership and united fully behind her."In March, Trump announced on Truth Social that Wiles had been diagnosed with early-stage breast cancer and that she would remain in her role at the White House during treatment."Her Strength and her Commitment to continue doing the job